Chromatography, Magnetic Resonance & Mass Spectrometry Provides the exact mass of the analyzed sample and therefore access to the sum formula The LC-NMR/MS setup was first introduced by Bruker BioSpin in 1999. An LC-NMR system including a Bruker Peak Sampling Unit (BPSU-36) was coupled with a Bruker Daltonics esquire series ion trap mass spectrometer via a Bruker NMR-MS interface (BNMI). Nowadays mostly maXis / micrOTOF time-of-flight mass spectrometers are used in hyphenated systems. | The time-of-flight mass spectrometers provides the exact mass of the analyzed sample and therefore access to the sum formula. This, together with the NMR spectrum for the compound, often already provides the answer to your questions. |